7,8-Dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(For export only)
7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione
CAS: 39713-40-1
Molecular Formula: C10H9NO2
7,8-Dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(For export only) - Names and Identifiers
7,8-Dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(For export only) - Physico-chemical Properties
| Molecular Formula | C10H9NO2 |
| Molar Mass | 175.18 |
| Density | 1.249 |
| Boling Point | 364.6±21.0 °C(Predicted) |
| pKa | 0.40±0.20(Predicted) |
| Storage Condition | Room Temprature |
7,8-Dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(For export only) - Reference Information
| Use | Cycloheptano [B] pyridine -5,9-dione is an organic intermediate, which can be made of 2,3-dimethyl pyridine dimethyl ester and dimethyl glutarate as starting materials, prepared by two-step reaction. |
| Preparation | Add potassium tert-butoxide (1.0 M THF,9.6 L,9.6mol) to toluene (5.25 L) solution of dimethyl 2, 3-pyridinedicarboxylate (750g,3.84 mol) and dimethyl glutarate (935g,5.84 mol) to maintain the internal temperature <30°C. The reaction mixture was heated to 55-60°C within 1 hour and held for 1 hour. The reaction mixture was concentrated to <7L under vacuum and then cooled to 0-5°C. Add n-heptane (11.3 L) to the concentrated reaction mixture, then add ice water (10.9 L), and maintain the internal temperature <5°C. The pH of the reaction mixture was then adjusted to 6.0-6.5 with glacial acetic acid (435ml) at 0-5°C. The resulting slurry was filtered and the filter cake was washed successively with water (2.3 L) and n-heptane (3.7 L) and then dried under vacuum at 50-55°C to give 5, 9-dihydroxy-7H-cycloheptyl [B] pyridine-6, 8-dicarboxylic acid dimethyl ester. White solid, yield 822g,73%. |
Last Update：2024-04-09 21:32:06
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Product Name: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione Request for quotationCAS: 39713-40-1
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Product Name: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione Visit Supplier Webpage Request for quotation
CAS: 39713-40-1
Tel: 18301782025
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Mobile: 18021002903
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CAS: 39713-40-1
Tel: 18301782025
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